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| Attiq,Ali; Ashraf,Muhammad; Jalil,Juriyati; Javeed,Aqeel; Anjum,Aftab Ahmad; Ullah,Asad; Umair,Muhammad; Ali,Sarwat. |
| Abstract It is understood that drugs regardless of their order of administration can exhibit drug interactions. Established on the fact that treatment of hypertension may last for decades and prolong usage of multiple drug regimen may induce substantial pathophysiological changes. Hence, This study was designed to evaluate the possible synergistic toxic effects of anti-hypertensive (carvedilol), and anti-inflammatory drug (celecoxib) alone and in combinations. Well-established MTT assay, Single Cell Gel Electrophoresis (SCGE) and Ames assay were employed to evaluate the toxicity at cellular level. Results from MTT assay on Vero cell line revealed that drug combinations have more pronounced anti-proliferative activity with combine IC50 value of 13.7:47.8... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carvedilol; Celecoxib; Mutagenicity; Genotoxicity; Cytotoxicity.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100622 |
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| Leomil Neto,Moacir; Pascoal,Lívia Aparecida D'Avila Bitencourt; Balieiro,Júlio César Carvalho; Larsson,Maria Helena Matiko Akao; Bombonato,Pedro Primo; Benedicto,Hildebrando Gomes; Elton,Lílian Barreto. |
| A estimulação catecolaminérgica precoce e excessiva do coração, que ocorre na insuficiência cardíaca congestiva, acentua a sobrecarga de pressão e o volume nos ventrículos, agravando, conseqüentemente, a isquemia miocárdica, causando morte de miócitos com deposição de tecido conjuntivo e progressiva redução do débito cardíaco. O carvedilol, um b e alfa1-bloqueador não cardio-seletivo, vem sendo associado a melhorias na função miocárdica e à regressão da hipertrofia ventricular esquerda. O objetivo do presente trabalho foi avaliar a ação do carvedilol em ratos submetidos a um modelo experimental de hipertrofia miocárdica por sobrecarga de pressão, por meio da coartação da aorta subdiafragmática. Ratos Wistar (65 animais) foram divididos em quatro grupos:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carvedilol; Hipertrofia miocárdica; Ratos; Coartação. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000400026 |
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| Soares,E.C.; Pereira,G.G.; Petrus,L.C.; Leomil Neto,M.; Yamaki,F.L.; Larsson,M.H.M.A.. |
| Sixty dogs with idiopathic dilated cardiomyopathy were randomly treated with traditional therapy - digitalis, diuretics, angiotensin-converting inhibitors - (group A) or treated with these drugs plus carvedilol (group B). Echocardiographic variables were measured before and after 3, 13, 26, and 52 weeks of treatment or until death. Comparisons between groups and time were performed. No significant differences between groups were found in the most of the echocardiographic variables. The left ventricular end-systolic diameter indexed to body surface area (LVESDi) increased significantly in the group A dogs compared to the group B animals. The survival of groups A and B dogs were not different (P-value=0.1137). In conclusion, the stability of the LVESDi... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Cardiomyopathy; Carvedilol; Heart failure; Echocardiography. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000300009 |
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